• V. P. Polyovyy
  • B. Khorshani
  • V. V. Petrynych
  • P. V. Kyfyak
  • O. V. Tkachuk
  • R. I. Sydorchuk
Keywords: diabetic foot syndrome, wound process, morphology, pathogenesis, diagnosis.


Summary. Diabetic foot syndrome (DFS) is one of the most common surgical diseases.

The aim of the study: to determine the features of the wound process in the DFS.

Materials and methods. Multimodal pathomorphological study of biopsy material in 120 cases of surgical treatment of DFS was performed.

Results and discussion. During the development of the wound process in the DFS, histologically determined reduction of edema, cellular infiltration, microcirculatory disorders in the marginal area of the wound in the dynamics of treatment. It is found in granulation tissue and in the dermis adjacent to intact skin, a large number of hairy cells. Microcirculatory disorders are expressed in the form of venular plethora, the phenomena of stasis in the capillaries, hemolysis of erythrocytes and the marginal standing of the formed elements in the venules and capillaries. The DFS is characterized by the appearance of foci of destruction and lysis of the newly formed epithelium, which is not observed in the normal wound process.

Conclusions. The formation of granulation tissue is slow, mainly in the form of unformed connective tissue without the formation of classic granulations.


1. Causey MW, Ahmed A, Wu B, et al. Society for Vascular Surgery limb stage and patient risk correlate with outcomes in an amputation prevention program. J Vasc Surg. 2016; 63: 1563-1573.
2. Dumville JC, Lipsky BA, Hoey C, Cruciani M, Fiscon M, Xia J. Topical antimicrobial agents for treating foot ulcers in people with diabetes. Cochrane Database Syst Rev. 2017; CD011038.
3. Guthrie HC, Clasper JC. Historical origins and current concepts of wound debridement. J R Army Med Corps. 2011; 157: 130-132.
4. Khomko OY, Sydorchuk RI, Karateieva SY, Makarova EV, Bilyk II, Khomko BO. Ozone application in multimodal treatment of pyoinflammatory complications in patients with diabetes mellitus. European applied sciences. 2014; 1: 41-42.
5. Schaper NC, van Netten J, Apelqvist J, et al. on behalf of the International Working Group on the Diabetic Foot (IWGDF). IWGDF Guidelines on the Prevention and Management of Diabetic Foot Disease. Accessed online 23.02.2020 from https://iwgdfguidelines.org/wp-content/uploads/2019/05/01-IWGDF-practical-guidelines-2019.pdf
6. Sydorchuk RI, Sydorchuk LP, Khorshani Bilel, Hrushko OI, Plehutsa OM, Sydorchuk I, Plehutsa IM, Vakarchuk AV, Sydorchuk AR, Ilaschuk II, Plehutsa N. Microbiota alleviates host resistance and causes septic complications in diabetic foot syndrome. Infection. 2019; 47(Suppl. 1): S 57-58.
7. van Netten JJ, Lazzarini PA, Armstrong DG, et al. Diabetic Foot Australia guideline on footwear for people with diabetes. J Foot Ankle Res. 2018; 11: 2.
How to Cite
Polyovyy, V. P., Khorshani, B., Petrynych, V. V., Kyfyak, P. V., Tkachuk, O. V., & Sydorchuk, R. I. (2020). FEATURES OF THE EARLY PROCESS IN DIABETIC FOOT SYNDROME. Kharkiv Surgical School, (2), 21-25. https://doi.org/10.37699/2308-7005.2.2020.04