THE INFLUENCE OF HYALURURIC ACID ON THE MORPHOLOGICAL FEATURES OF THE GRANULATION TISSUE OF THE LAPAROTOMIC WOUND WITH THE USE OF SIMPLE NODAL JOINTS
Resume. This article presents the results of an experimental study of the effect of topical application of hyaluronic acid on the morphological features of laparotomy granulation tissue when sewing the latter with simple nodal sutures.
The experiment was performed on 108 laboratory rats, which underwent a median laparotomy and reduced the edges of the musculo-aponeurotic layer of the anterior abdominal wall with simple nodal sutures. The animals of the main group were treated with a colorless, transparent, viscous hyaluronic acid gel, on the sutures of the musculoskeletal layer.
It is established that the local application of hyaluronic acid in the suturing of the edges of the musculoskeletal layer with the help of simple nodal sutures leads to inhibition of maturation of granulation tissue, since there is a probable decrease in the percentage of fibroblasts and macrophages, specific volume and optocoupler specific volume of blood vessels.
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