• M. I. Pokidko
  • T. V. Formanchuk
  • A. G. Sychevska
  • O. B. Tkachenko
Keywords: acute pancreatitis, diagnosis, general mortality.


Summary. The purpose of the study: to analyze the causes of development, terms of hospitalization, the frequency of severe type, complications and overall mortality in acute pancreatitis according to the clinic data.

Materials and methods: the results of treatment of 622 patients with acute pancreatitis were analyzed. Among them there were 336 women (54.1 %) and 286 men (45.9 %). The mean age of patients was (48.2 ± 2.2) years. The diagnosis of acute pancreatitis was made according to the recommendations (Atlanta, 2012). All patients with acute pancreatitis underwent ultrasound examination of the abdominal cavity and computed tomography, enhanced by intravenous contrast.

Results and discussion: Etiological factors of acute pancreatitis were: biliary factor in 270 (43.4 %) patients, alcohol — in 155 (24.9 %), acute pancreatitis on the background of triglyceridemia — in 135 patients (21.7 %), 21 (3.4 %) patients had postoperative pancreatitis, medication — in 8 (1.3 %) patients and without a clear etiology — in 33 (5.3 %) patients. The terms of hospitalization of patients are as follows: after 24–48 hours from the onset of the disease — 215 (34.6 %) cases, after 6–24 hours after the onset of the disease — 204 (32.8 %) cases, after 48 hours and later from the time of the disease — 129 (20.7 %) cases and 74 (11.9 %) cases of hospitalization up to 6 hours from the onset of the disease. Severe acute pancreatitis developed in 147 (23.6 %) patients and was accompanied by the development of organ failure lasting > 48 hours. 594 (95.4 %) patients with acute pancreatitis received only conservative infusion therapy. 28 (4.5 %) patients required surgical treatment. The overall mortality in patients with acute pancreatitis was 9 (1.4 %) cases.

Conclusions: Hyperdiagnosis of acute pancreatitis is a common problem in modern surgery. Formulation of the diagnosis according to the unified diagnostic criteria considerably facilitated diagnosis. The dominant factors of acute pancreatitis are biliary (43.4 %) and alcoholic factors (24.9 %). Most often (34.6 %) patients were admitted to the department on the second day after the onset of the disease. Remains high level of severe acute pancreatitis, which amounted to 23.6 % of cases. 594 (95.4 %) patients with acute pancreatitis received infusion therapy. 28 (4.5 %) patients underwent surgical treatment. The total mortality in acute pancreatitis according to our clinic was 9 (1.4 %) cases, the majority of them (7 patients) died in the early period of acute pancreatitis.


1. Cifci M, Halhalli H. The relationship between neutrophil-lymphocyte and platelet-lymphocyte ratios with hospital stays and mortality in the emergency department. CUREUS. 2020;12(12). N article e12179. DOI: 10.7759/cureus.12179.
2. Fonseca Sepulveda EV, Guerrero-Lozano R. Acute pancreatitis and recurrent acute pancreatitis: an exploration of clinical and etiologic factors and outcomes. J Pediatr (Rio J) 2018;95:713-9.
3. Nesvaderani M, Eslick GD, Vagg D, et al. Epidemiology, aetiology and outcomes of acute pancreatitis: a retrospective cohort study. Int J Surg 2015;23:68-74.
4. Cho YS, Kim HK, Jang EC, et al. Usefulness of the bedside index for severity in acute pancreatitis in the early prediction of severity and mortality in acute pancreatitis. Pancreas 2013;42:483-7.
5. Vasudevan S, Goswami P, Sonika U, et al. Comparison of various scoring systems and biochemical markers in predicting the outcome in acute pancreatitis. Pancreas 2018; 47: 65-71.
6. Karakayali FY. Surgical and interventional management of complications caused by acute pancreatitis. World J Gastroenterol 2014;20:13412-23.
7. Banks PA, Bollen TL, Dervenis C, et al. Classification of acute pancreatitis —2012: revision of the Atlanta classification and definitions by international consensus Gut 2013; 62:102-11. doi:10.1136/gutjnl-2012-302779.
8. Colvin SD, Smith EN, Morgan DE, Porter KK. Acute pancreatitis: an update on the revised Atlanta classification. ABDOMINAL RADIOLOGY. May, 2020. Vol. 45, Issue 5. P. 1222-31.
9. Leppaniemi A, Tolonen M, Tarasconi A, Segovia-Lohse H, Gamberini E, Kirkpatrick AW, et al. WSES guidelines for the management of severe acute pancreatitis. World journal of emergency surgery. 2019;14(27). DOI: 10.1186/ s13017-019-0247-0.
10. Vinnik YuS, Dunaevskaya SS, Antyufrieva DA, Deulina VV. Razvitie rannej organnoj nedostatochnosti pri nekrotiziruyushhem ostrom pankreatite. Sovremenny`e problemy` nauki i obrazovaniya.2018;4.URL: [In Ukr.].
11. Gorlach AI`, Dronov OI`, Koval`s`ka I`O, Zadorozhna KO. Maloi`nvazivni` khi`rurgi`chni` vtruchannya pri gostromu nekrotichnomu pankreatiti`: i`stori`ya rozvitku, suchasni` tendenczi`yi ta vlasnij dosvi`d. Vi`snik Vi`nnicz`kogo naczi`o-nal`nogo medichnogo uni`versitetu. 2017;1(1):172-7 [In Ukr.].
12. Krivoruchko IA, Balaka SN, Sy`kal NA, Povelichenko MS. Lechenie destruktivnogo pankreatita s ispol`zovaniem maloinvazivny`kh tekhnologij. VI`SNIK VDNZU «Ukra-yins`ka medichna stomatologi`chna akademi`ya», 112-4.
13. Huazhi LI, Yongzhe WU, Chen XU, Hongchao AN, Chunhai GUO and Hongli Cui. Early ultrasound-guided percutaneous catheter drainage in the treatment of severe acute pancreatitis with acute fluid accumulation. Experimental and therapeutic medicine. 2018;16:1753-7, DOI: 10.3892/etm.2018.6398 [In Ukr.].
14. Li X , Wang LP ,Tan Z, Xu YX, Yu F, Han XT, et al. Percutaneous Catheter Drainage of Pancreatic Fluid Collections in Patients with Acute Pancreatitis. Indian journal of surgery. Published.2020:22. DOI: 10.1007/s12262-020-02187-x.
How to Cite
Pokidko, M. I., Formanchuk, T. V., Sychevska, A. G., & Tkachenko, O. B. (2021). STRUCTURAL ANALYSIS OF CLINICAL AND LABORATORY AND INSTRUMENTAL DIAGNOSIS AND TREATMENT OF ACUTE PANCREATITIS. Kharkiv Surgical School, (1), 52-58.