ANALYSIS OF POLYMORPHISM OF MATRIX METALLOPROTEINASE-2 (C-1306 → T) AND TISSUE INHIBITORS OF METALLOPROTEINASE-2 (G1303→ A) GENES IN PATIENTS WITH EVENTRATION

  • Ya. Voitiv
  • O. Usenko
  • V. Dosenko
Keywords: eventration, MMP-2, TIMR-2, gene polymorphism.

Abstract

Summary. The aim. To analyze the frequency of polymorphic variants of matrix metalloproteinase-2 (C-1306→T) (MMP-2) and tissue matrix metalloproteinase-2 (G303→A) (TIMP-2) genes in patients with eventration.

Materials and methods. The study included 11 patients with eventration and 44 patients with connective tissue pathology. Laboratory, genetic and statistical studies were performed.

Results and discussion. All models of inheritance are analyzed and the best model with the lowest information criterion Aikaike, which turned out to be a recessive model, is determined.

Conclusions. As a result of genetic and statistical analysis of polymorphism of MMP-2 (C-1306→T) and TIMP-2 (G303→A) genes, it was found that polymorphic variants of these genes are not reliably associated with the development of eventration.

References

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Published
2020-10-12
How to Cite
Voitiv, Y., Usenko, O., & Dosenko, V. (2020). ANALYSIS OF POLYMORPHISM OF MATRIX METALLOPROTEINASE-2 (C-1306 → T) AND TISSUE INHIBITORS OF METALLOPROTEINASE-2 (G1303→ A) GENES IN PATIENTS WITH EVENTRATION. Kharkiv Surgical School, (4), 9-14. https://doi.org/10.37699/2308-7005.4.2020.02
Section
QUESTIONS OF GASTROINTESTINAL TRACT